EP Patent

EP0482939A1 — Isoquinolinone derivative

Assigned to Ono Pharmaceutical Co Ltd · Expires 1992-04-29 · 34y expired

What this patent protects

Isoquinolinone derivatives of the formula: wherein R¹ is hydrogen, C1-4 alkyl, C1-4 alkoxy or a group of formula:         -NR⁴R⁵ wherein R⁴ is hydrogen, halogen, C1-4 alkyl or C2-4 alkanoyl and R⁵ is hydrogen, C1-4 alkyl or benzyl; R² is hydrogen or C1-4 alkyl; …

USPTO Abstract

Isoquinolinone derivatives of the formula: wherein R¹ is hydrogen, C1-4 alkyl, C1-4 alkoxy or a group of formula:         -NR⁴R⁵ wherein R⁴ is hydrogen, halogen, C1-4 alkyl or C2-4 alkanoyl and R⁵ is hydrogen, C1-4 alkyl or benzyl; R² is hydrogen or C1-4 alkyl; R³ is hydrogen or C1-4 alkyl; l is 1, 2, 3 or 4; m is 1 or 2; n is 1 or 2 and --- is a single bond or double bond and non-toxic acid addition salts thereof and hydrates thereof possess an antagonistic activity against 5-HT3 receptor, and are useful for the prevention and/or treatment of diseases induced when 5-HT acts on 5-HT3 receptors (especially vomiting induced by the administration of an anti-cancer agent).

Drugs covered by this patent

Patent Metadata

Patent number
EP0482939A1
Jurisdiction
EP
Classification
—
Expires
1992-04-29
Drug substance claim
No
Drug product claim
No
Assignee
Ono Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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