EP0480729A1 — Microencapsulation for controlled oral drug delivery system
Assigned to Korea Research Institute of Chemical Technology KRICT · Expires 1992-04-15 · 34y expired
What this patent protects
The present invention provides a microencapsulation method of an oil droplet containing drugs for oral administration using polysaccharide which has metal-chelating capacity and the biocompatible and water-soluble polymer as a capsule material. The drug carrier system obtained in…
USPTO Abstract
The present invention provides a microencapsulation method of an oil droplet containing drugs for oral administration using polysaccharide which has metal-chelating capacity and the biocompatible and water-soluble polymer as a capsule material. The drug carrier system obtained in this invention using the microencapsulated emulsion represses the drug release from the system and protects the emulsion and drug from the strong acidic condition of gastric juice. The oil droplet and drug dispersed in the oil droplet was released rapidly in the small intestine with the disintegration of capsule material. The system obtained in this invention can reduce the gastric upset or damages on the stomach and protect drugs from the degradation in the gastric juice. At the same time, the degradation of drug caused by the hepatic first-pass metabolism can be lessened because the drug dispersed in oil droplet can be absorbed via lymphatic absorption.
Drugs covered by this patent
- Prilosec (omeprazole) · AstraZeneca (originally Astra AB)
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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