EP Patent

EP0475482A1 — Stabilized solid chemical compositions

Assigned to Organon NV · Expires 1992-03-18 · 34y expired

What this patent protects

Disclosed are stabilized dry chemical (e.g. pharmaceutical) compositions containing the water soluble acid addition salt of a poorly soluble basic compound (e.g. mianserin, apomorphine, chlorpromazine, imipramine, or promethazine); an excipient selected from the group consisting …

USPTO Abstract

Disclosed are stabilized dry chemical (e.g. pharmaceutical) compositions containing the water soluble acid addition salt of a poorly soluble basic compound (e.g. mianserin, apomorphine, chlorpromazine, imipramine, or promethazine); an excipient selected from the group consisting of microcrystalline cellulose, lactose, calcium hydrogen phosphate, and mixtures thereof; and a water soluble (> 2mg/ml) alkaline stabilizer. The dry composition is relatively more stable than one not containing the water soluble alkaline stabilizer, especially after a high temperature granulation process. The process for preparing the dry composition is also more "rugged" with the added water soluble alkaline stabilizer.

Drugs covered by this patent

Patent Metadata

Patent number
EP0475482A1
Jurisdiction
EP
Classification
—
Expires
1992-03-18
Drug substance claim
No
Drug product claim
No
Assignee
Organon NV
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.