EP0468690A1 — Pyrimidine derivatives

USPTO Abstract

A pyrimidine derivative has the formula, wherein each of R¹ and R², which may be the same or different, is C₁-C₆ alkyl, C₁-C₆ alkoxy, halo C₁-C₆ alkoxy or halogen;    R³ is hydrogen or C₁-C₆ alkyl;    R⁴ is C₁-C₆ alkyl, halo C₁-C₆ alkyl, benzyl, phenyl or phenyl substituted with at least one member selected from the group consisting of C₁-C₆ alkyl, C₁-C₆ alkoxy, halo C₁-C₆ alkyl, C₁-C₆ alkoxycarbonyl, nitro and halogen;    X is oxygen or sulfur;    Z is nitrogen or CY⁴;    each of Y¹, Y² and Y³, which may be the same or different, is hydrogen, halogen, C₁-C₆ alkyl or C₁-C₆ alkoxy; and    Y⁴ is hydrogen, hydroxyl, mercapto, nitro, halogen, C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₁-C₆ alkoxy, C₃-C₆ alkenyloxy, C₃-C₆ alkynyloxy, halo C₁-C₆ alkyl, halo C₂-C₆ alkenyl, halo C₂-C₆ alkynyl, halo C₁-C₆ alkoxy, halo C₃-C₆ alkenyloxy, halo C₃-C₆ alkynyloxy, C₁-C₆ alkoxy C₁-C₆ alkyl, C₃-C₆ alkenyloxy C₁-C₆ alkyl, C₃-C₆ alkynyloxy C₁-C₆ alkyl, cyano, formyl, carboxyl, C₁-C₆ alkoxycarbonyl, C₃-C₆ alkenyloxycarbonyl, C₃-C₆ alkynyloxycarbonyl, phenyl, phenyl substituted with at least one member selected from the group consisting of C₁-C₆ alkyl, C₁-C₆ alkoxy, halo C₁-C₆ alkyl, C₁-C₆ alkoxycarbonyl and halogen, phenoxy, phenoxy substituted with at least one member selected from the group consisting of C₁-C₆ alkyl, C₁-C₆ alkoxy, halo C₁-C₆ alkyl, C₁-C₆ alkoxycarbonyl and halogen, phenylthio, phenylthio substituted with at least one member selected from the group consisting of C₁-C₆ alkyl, C₁-C₆ alkoxy, halo C₁-C₆ alkyl, C₁-C₆ alkoxycarbonyl and halogen, benzyloxy, benzyloxy substituted with at least one member selected from the group consisting of C₁-C₆ alkyl, C₁-C₆ alkoxy, halo C₁-C₆ alkyl, C₁-C₆ alkoxycarbonyl and halogen, benzylthio, benzylthio substituted with at least one member selected from the group consisting of C₁-C₆ alkyl, C₁-C₆ alkoxy, halo C₁-C₆ alkyl, C₁-C₆ alkoxycarbonyl and halogen, wherein each of R⁵ and R⁶, which may be the same or different, is hydrogen, C₁-C₆ alkyl, C₃-C₆ alkenyl or C₃-C₆ alkynyl, wherein R⁵ and R⁶ are as defined above, wherein R⁷ is C₁-C₆ alkyl, C₃-C₆ alkenyl or C₃-C₆ alkynyl and m is an integer of 0, 1 or 2, wherein X¹ is oxygen or sulfur, and R⁷ is as defined above, or wherein R⁷ and m are as defined above, and n is an integer from 1 to 4.