EP0466452A2 — Thioxo heterocycles and their pharmaceutical use

USPTO Abstract

The invention concerns a thioxo heterocycle of the formula I wherein Q is a 10-membered bicyclic heterocyclic moiety containing 1 or 2 N's which bears 1 or 2 thioxo substituents and which is optionally further substituted ; A 1 is a direct link to X 1 or (1-3C)alkylene ; X 1 is oxy, thio, sulphinyl, sulphonyl or imino; Ar is optionally substituted phenylene or pyridylene ; R 1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and R 2 and R 3 together form a group of the formula -A 2- X 2 -A 3- which, together with the carbon atom to which A 2 and A3 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A 2 and A3 is (1-3C)alkylene and X 2 is oxy, thio, sulphinyl or sulphonyl ; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.