EP0434999A1 — Cycloheptenopyridine derivatives, process for preparation thereof and antiulcer agents containing the same

USPTO Abstract

Provided are cycloheptenopyridine derivatives represented by the general formula [wherin R represents a hydrogen atom or lower alkyl group; R 1 represents a hydrogen atom, hologen atom, lower alkoxy group, lower cycloalkoxy group, amido group, substituted phenoxy group, substituted benzyloxy group, lower alkoxy group optionally containing halogen atom(s), nitro group, hydroxyl group, lower alkenyloxy group, lower alkylthio group, or group-NR4Rs (wherein R 4 and R 5 may be the same or different and each represent a hydrogen atom or lower alkyl group, or R 4 and R 5 mutually combine together with the nitrogen atom adjacent thereto to form a 5- or 6- membered cycle); R 2 represents a hydrogen atom, halogen atom, lower alkyl group optionally containing a halogen atom, lower alkoxy group optionally containing a halogen atom, hydroxyl group, acyl group, lower alkoxycarbonyl group, nitro group or amino group; R 3 represents a lower alkyl group, lower alkoxymethyl group, lower alkylcarbonyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkylcarbamoyl group, lower alkylcarbonylmethyl group, lower alkoxycarbonylmethyl group, lower acyloxymethyl group, lower alkylsulfonyl group, or physiologically acceptable protective group eliminable in an acid medium or under a physiological condition; n represents 0 or 1; and A represents a methine carbon or nitrogen atom] or their salts. These derivatives and their salts are useful as untiulcer agents.