EP Patent

EP0431679A1 — Method of stabilizing recombinant hepatitis B virus surface proteins from yeast

Assigned to Merck and Co Inc · Expires 1991-06-12 · 35y expired

What this patent protects

Recombinant hepatitis B virus surface proteins produced in yeast are rapidly and efficiently purified from yeast cell extracts in a high pH buffer. The yeast cell extract is heat treated, cooled and the pH is reduced. The surface proteins are then adsorbed onto wide pore silica f…

USPTO Abstract

Recombinant hepatitis B virus surface proteins produced in yeast are rapidly and efficiently purified from yeast cell extracts in a high pH buffer. The yeast cell extract is heat treated, cooled and the pH is reduced. The surface proteins are then adsorbed onto wide pore silica followed by elution and concentration. This method eliminates the requisite introduction of protease inhibitors, stabilizes the surface protein and improves product yield.

Drugs covered by this patent

Patent Metadata

Patent number
EP0431679A1
Jurisdiction
EP
Classification
—
Expires
1991-06-12
Drug substance claim
No
Drug product claim
No
Assignee
Merck and Co Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.