EP0415566A1 — Heterocyclic compounds, processes for producing them and pharmaceutical compositions comprising them

USPTO Abstract

Novel heterocyclic compounds capable of lowenng the und acid levels in plasma and unne having the formula (I) wherein R 2 and R 2 are independently hydrogen, lower alkyl, phenyl or substituted phenyl, or R' and R 2 may form a four to eight-membered carbon ring together with the carbon atom to which they are attached: R 3 is hydrogen or lower alkyl: R 4 is one or two radicals selected from a group consisting of hydrogen, halogen, nitro. lower alkyl. phenyl. substituted phenyl, -OR 5 and -SO 2 NR 6 R 6 ; R 5 is hydrogen. lower alkyl phenyl-substituted lower alkyl. carboxymethyl or ester thereof, hydroxethyl or ether thereof, or allyl; R 6 and R 6 are independently hydrogen or lower alkyl: R 7 is hydrogen or a pharmaceutically active ester-forming group: A is a straight or branched hydrocarbon radical having one to five carbon atoms: B is halogen. oxygen, or dithiolane; Y is oxygen. sulfur, nitrogen or substituted nitrogen; Z is oxygen, nitrogen or substituted nitrogen: dotted line represents the presence or absence of a single bond, processes for their production and pharmaceutical compositions comprising them.