EP0412404A2 — Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same

USPTO Abstract

A compound of the formula : wherein R¹ is hydrogen or acyl which may be substituted with halogen, R² is hydrogen, lower alkyl, hydroxy(lower)alkyl, halogen or carboxy, A is -CH₂-, -CO-, -C(=NOR⁴)- [wherein R⁴ is lower alkyl, [wherein m is 0, 1 or 2], and R³ is aryl which may be substituted with halogen, hydroxy, lower alkoxy, nitro, amino or acylamino; or N-containing unsaturated heterocyclic group which may be substituted with lower alkyl, amino, hydroxy or halo(lower)alkyl, and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in admixture with pharmaceutically acceptable carriers.