EP0383919A1 — Staurosporin derivatives

USPTO Abstract

Novel staurosporin derivatives represented by formula (I) (wherein R<1> represents hydrogen, lower alkyl, formyl or amino, R<2> represents hydrogen, formyl, lower alkanoyl or a group formed by removing a hydroxy moiety from the carboxyl group of an alpha -amino acid whose amino group may optionally be protected, one of X<1> and X<2> represents hydrogen and the other represents hydrogen, hydroxy, lower alkoxy or lower alkylthio, or X<1> and X<2> are taken together to form oxygen, provided that, when R<1> and R<2> are both hydrogen atoms and one of X<1> and X<2> is hydrogen, the other represents a group other than hydrogen or hydroxy) and their pharmacologically acceptable salts are disclosed. These compounds inhibit protein kinase C and have a cell growth inhibiting activity.