EP0381181A2 — A system for the controlled release of active agents and a process for its preparation

USPTO Abstract

The invention relates to a system for the controlled release of active agents and a process for its preparation, pref­erably an orally administrable pharmaceutical preparation for various, especially soluble, pharmaceutical agents, hav­ing even, controlled active agent release essentially caused by convective processes. The system of the invention is similar in therapeutic effec­tivity to an intravenous drip, i.e. the even and complete release of the active agent from the pharmaceutical prepara­tion for a physiologically and therapeutically practical period of time caused by essentially convective processes. This leads to a constant therapeutic blood level which gua­rantees the long-term effect of the drug whilst reducing the adverse effects and improving local tolerance in the gas­trointestinal tract at the same time. Furthermore, with the composition according to the invention of the pharmaceutical preparation and the preparation pro­cess according to the invention, damages to the shell con­trolling the release of the pharmaceutical agent will not lead to dose-dumping, as is usually the case in membrane-­controlled pharmaceutical agent release, and the preset re­lease rate will be reached within a short period of time.