EP0369409A1 — Carbocyclic nucleosides and nucleotides

USPTO Abstract

The invention relates to 1-B-4-phosphonylmethoxycyclopentane compounds having Formula I or Formula II wherein R¹ and R² are independently hydrogen, hydroxy, chlorine, bromine, or an organic substituent having 1 to 5 carbon atoms and selected from carbacyloxy, alkoxy, alkylthio, amino, alkylamino and dialkylamino, R³ and R⁴ are independently hydrogen, or organic phosphonic ester substituents having 1 to 12 carbon atoms and selected from alkyl, alkenyl, aryl, and aralkyl, B is a heterocyclic group having at least one nitrogen heteroatom and up to three additional heteroatoms selected from nitrogen, oxygen and sulfur, said heterocyclic group being attached through a nitrogen heteroatom thereof, and the pharmaceutically acceptable acid addition, metal, and amine salts thereof. These compounds are useful for treating viral diseases and diseases of microbial origin. They are also effective against infections conditions and tumors.