EP0339976A1 — Anti-tumour agents

USPTO Abstract

The invention relates to quinazoline derivatives which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula:- wherein R¹ is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R¹ is substituted alkyl or alkoxy each of up to 3 carbon atoms; R² is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl or halogenoalkyl each of up to 6 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula -CO.NH- or CO.NR³-, wherein R³ is alkyl of up to 6 carbon atoms; and Y is hydrogen or alkyl, cylcoalkyl, alkenyl or alkynyl each of up to 6 carbon atoms; or Y is a group of the formula -A-Y¹ in which A is alkylene of up to 6 carbon atoms and Y¹ includes hydroxy, amino and cyano, and alkoxy, alkylamino and alkylthio each of up to 6 carbon atoms.