EP0300688A1 — Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them

USPTO Abstract

Compounds of formula I, wherein R₁, R₂, R₃ and R₅ have the meanings defined in the specification, G2 represents a chain -(CH₂) z (W) y -, in which W has various meanings including C=O, and up to two of the methylene segments in the chain (CH₂) z are optionally replaced by -NH- and one segment is optionally replaced by -O- or -(C=NR₄₀)-, and the chain is optionally unsaturated and optionally substituted, and A is a 5- or 6-membered ring or a bicyclic or tricyclic fused ring system, A being optionally substituted by various substituents, possess useful pharmacological properties, in particular as cardiotonics. Also described are processes for the preparation of compounds of formula I, pharmaceutical compositions containing them and methods of treatment involving their use.