EP0207581A2 — Thiazolidine derivatives, their preparation and use

USPTO Abstract

Compounds of formula (I):(in which R<sup>1</sup>-R<sup>7</sup> are hydrogen or various organic groups, n is 1-10, Ar is an aromatic group, U is CH2 or a carbon atom doubly bonded to either one of its adjacent carbons, and W is >CH<sub>2</sub>, >C=O, >CHOH, >C=<sub>NOH</sub> or various derivatives thereof) have the ability to lower the levels of blood lipid peroxides and blood sugars and to inhibit the activity of aldose reductase; they may be used therapeutically for these purposes. They may be prepared by reacting a corresponding compound where the thiazolidine ring is replaced by a group - C(R<sup>7a</sup>)X-A (where X is halogen, R<sup>7a</sup> is similar to R<sup>7</sup> and A is carboxy or similar) with thiourea.