EP0164593A1 — Anti-inflammatory phthalazinones

USPTO Abstract

A compound useful as anti-inflammatory agefits in warm- blooded animals of the formula wherein X is a member of the class of ethylene and ethenyl and is substituted for hydrogen in the sixth or seventh position of the 1(2H)-phthalazinone ring Y is a member of the class of hydrogen and hydroxyl R, is a member of the class of hydrogen, alkyl, alkoxy, hydroxyl, halogen, nitro, -NR 3 R 4 , -COR 5 and -0-A wherein A is a mineral acid residue which with -0- forms an ester or the alkali metal salt of said ester, R 2 is a member of the class of hydrogen, alkyl, phenyl, substituted phenyl, heteroaryl, hydroxyalkylene, polyhydroxyalkylene, aminoalkylene, alkylaminoalkylene, and carboxyalkylene, R 3 , R 4 , are independently from the class of hydrogen, alkyl, aminoalkylene or alkylaminoalkylene, R 5 is a member of the class of OR 3 and for example hydroxyl, methoxyl, 2-dimethylaminoethoxyl or 2-dimethylaminoethylamino, and wherein by alkyl and alkylene is meant respectively a mono- or divalent saturated aliphatic radical containing up to about eight carbon atoms, wherein the nitrogen of the alkylamino or alkylaminoalkylene may form a heterocycle with the alkyl or alkylene groups, wherein substituted phenyl may be substituted by, for example, alkyl, hydroxyl, alkoxy, halogen, nitro or amino, wherein heteroaryl may be, for example, 2-pyridyl.