EP0142146B1 — Oxo-analogs of mevinolin-like antihypercholesterolemic agents

USPTO Abstract

Mevinolin-like compounds of the structural formula: <CHEM> are disclosed wherein: R<1> is, e.g., hydrogen or C1-4alkyl; E is -CH2CH2, -CH=CH-, or -(CH2)3-; and Z is <CHEM> wherein X is -O-or-NR<9> wherein R<9> is hydrogen or C1-3alkyl; R<7> is C2-8alkyl; and R<8> is hydrogen or -CH3; <CHEM> wherein R<1><0>, R<1><1> and R<1><2> are independently, e.g., hydrogen, halogen or C1-4alkyl; <CHEM> wherein n is 0-2 and R<1><4> is halo or C1-4alkyl; or <CHEM> wherein the dotted lines represent possible double bonds there being 0, 1 or 2 double bonds; m represents 1, 2 or 3; and R<1><5> is methyl, hydroxy, C1-4alkoxy, oxo, or halo. Those compounds are potent HMG-CoA reductase inhibitors possessing one less asymmetric centre.