EP0139676B1 — Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins

USPTO Abstract

Production, detection of, and characterization of monoclonal antibodies/hybridoma antibodies (and the corresponding hybridoma cells including derived hybrid cells) which are able to recognize proteins (or part(s) thereof) belonging antigenically to the Human Leukocyte Interferon System (HuIFN-alpha) - be the said proteins produced natively (for example by white blood cells) or produced by recombinant techniques (genetic engineering) or produced by peptide derivation of the said proteins or part(s) thereof) - exhibiting the same common antigenic determinant(s) as found to be common in the native HuIFN-alpha system. Such antibodies (or the relevant part(s) thereof) can be used as "universal" antibodies for purification and characterization of all the above mentioned proteins belonging to the HuIFN-alpha system.