EP0123402A2 — Pyrimidine derivatives, preparation thereof and use thereof

USPTO Abstract

New pyrimidine derivatives of the formula: wherein Z is a group selected from in which R 1 and R 2 are each hydrogen, alkenyl, ar (lower) alkyl or lower alkyl optionally substituted with epoxy, hydroxy, amino and/or lower alkylamino and R 5 is lower alkyl, R' is hydrogen, aryl optionally substituted with lower alkyl, lower alkoxy a nd/o r halogen, or pyridyl optionally substituted with lower alkyl, R 4 is hydrogen, lower alkyl or phenyl optionally substituted with lower alkoxy, and Y is =0, =S or =N-R 6 , in which R 6 is lower alkyl; cyclo(lower)alkyl; ar(lower)alkyl optionally substituted with lower alkoxy; N-containing unsaturated heterocyclic group optionally substituted with lower alkyl; or aryl optionally substituted with hydroxy, lower alkyl, halogen or lower alkoxy, in which lower alkoxy substituent may be substituted with epoxy, hydroxy, amino and/or lower alkylamino, provided that Y is =N-R 6 when R 5 and R 4 are each hydrogen, and Y is =S or =N-R 6 when R' and R 2 are each hy d - rogen or lower alkyl and R 5 is phenyl, and pharmaceutically acceptable salts thereof, and processes for preparation thereof nad pharmaceutical composition comprising the same. These derivatives and salts thereof are useful as cardiotonic, antihypertensive agent, cerebrovascularvasodilator and anti-platelet agent.