EP0116208A1 — Mitomycin analogues

USPTO Abstract

Compounds of the general formula: {wherein X represents a group [in which R 3 represents a cycloalkyl or straight chain or branched alkyl group having up to 7 carbon atoms, said alkyl or cycloalkyl group optionally carrying 1 to 3 amino groups and/or 1 to 3 hydroxyl groups; a -(CH 2 ) n CO 2 R 4 group (in which n is the integer 1, 2 or 3, and R 4 represents a methyl or ethyl group); a pyridyl group; or a group of the formula: and R, and R 2 which may be the same or different, each represents a hydrogen atom or a methyl group, and indicates a or β bonding] possess good antibacterial and anti-tumor activity. The compounds of formula I may be prepared for example by reaction of mitomycin A, B, F or J with the appropriate amine.