EP0069600A2 — Pharmaceutical compositions
Assigned to Reckitt Benckiser Healthcare UK Ltd · Expires 1983-01-12 · 43y expired
What this patent protects
A pharmaceutical composition for sublingual administration comprising buprenorphine or a non-toxic salt thereof dissolved in 20-30% v/v aqueous ethanol buffered to between pH 4.5 to 5.5 with 0.05 to 0.2 molar concentration of a buffering agent selected from citric acid/disodium h…
USPTO Abstract
A pharmaceutical composition for sublingual administration comprising buprenorphine or a non-toxic salt thereof dissolved in 20-30% v/v aqueous ethanol buffered to between pH 4.5 to 5.5 with 0.05 to 0.2 molar concentration of a buffering agent selected from citric acid/disodium hydrogen phosphate, sodium citrate/hydrochloric acid, lactic acid/ disodium hydrogen phosphate, lactic acid/sodium lactate, sodium citrate/citric acid and sodium acetate/acetic acid, the concentration of buprenorphine being between 0.8 and 10 mg/ml of the composition. Buprenorphine is a potent antagonist analgesic with good bioavailability following sublingual administration, useful in the relief of moderate to severe pain and also in the treatment of natcotic addiction. The compositions enable higher doses of buprenorphine to be administered sublingually.
Drugs covered by this patent
- Subutex (Buprenorphine Hydrochloride) · Indivior
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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