EP0029310A1 — Cyclic hexapeptide somatostatin analogs, process for their preparation and pharmaceutical compositions containing them

USPTO Abstract

Novel somatostatin analogs are cyclic hexapeptides containing a secondary amino acid which replaces seven of the ring amino acids of somatostatin, together with certain other modifications to the molecule. The cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and in some cases have a greater level of activity, than somatostatin. They are used, preferably in pharmaceutical compositions, to inhibit the release of glucagon, growth hormone and insulin and certain of them are capable of inhibiting the release of gastric acid secretions. They are prepared by the solid phase method.