CN Patent

CN1613849A — 2－氯－5－氟－烟酸酯及酸的制备方法

Assigned to Wuxi Apptec Co Ltd · Expires 2005-05-11 · 21y expired

What this patent protects

本发明涉及一种新的2－氯－5－氟－烟酸酯及酸制备方法。解决了即知方法的收率过低，路线长及使用异臭的硫醇的缺陷。技术解决方案是通过2，6－二氯－5－氟－烟酸及相关羧酸酯直接选择性脱掉6位上的氯原子，以及通过2－氯－5－氟－烟酸酯在碱性物质存在下水解为2－氯－5－氟－烟酸。化学反应式如上，主要用于制备2－氯－5－氟－烟酸酯及2－氯－5－氟－烟酸药物中间体。

USPTO Abstract

本发明涉及一种新的2－氯－5－氟－烟酸酯及酸制备方法。解决了即知方法的收率过低，路线长及使用异臭的硫醇的缺陷。技术解决方案是通过2，6－二氯－5－氟－烟酸及相关羧酸酯直接选择性脱掉6位上的氯原子，以及通过2－氯－5－氟－烟酸酯在碱性物质存在下水解为2－氯－5－氟－烟酸。化学反应式如上，主要用于制备2－氯－5－氟－烟酸酯及2－氯－5－氟－烟酸药物中间体。

Drugs covered by this patent

Patent Metadata

Patent number
CN1613849A
Jurisdiction
CN
Classification
—
Expires
2005-05-11
Drug substance claim
No
Drug product claim
No
Assignee
Wuxi Apptec Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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