CN Patent

CN120699157B — 一种治疗溃疡性结肠炎的恢复肠屏障功能抗体及其应用

Assigned to Ankang city central hospital · Expires 2025-12-16 · 0y expired

What this patent protects

本发明涉及生物医药技术领域，具体公开一种治疗溃疡性结肠炎恢复肠屏障功能的抗体及其应用。所述抗体为靶向Janus激酶1(JAK1)的VHH3纳米抗体，其氨基酸序列如SEQ ID NO:4所示。该抗体通过特异性结合JAK1抗原表位(SEQ ID NO:3)，可显著抑制促炎因子TNF‑α和IL‑6表达，促进结肠上皮Claudin‑1蛋白分布，恢复肠道屏障功能。动物实验表明：腹腔注射0.2‑1.8mg/kg VHH3可有效降低疾病活动指数(DAI)，且疗效呈剂量依赖性。与现有技术相比，本发明抗体亲和力达1.23nM，具有分子量小、穿透性强、免疫原性低等优势。

USPTO Abstract

本发明涉及生物医药技术领域，具体公开一种治疗溃疡性结肠炎恢复肠屏障功能的抗体及其应用。所述抗体为靶向Janus激酶1(JAK1)的VHH3纳米抗体，其氨基酸序列如SEQ ID NO:4所示。该抗体通过特异性结合JAK1抗原表位(SEQ ID NO:3)，可显著抑制促炎因子TNF‑α和IL‑6表达，促进结肠上皮Claudin‑1蛋白分布，恢复肠道屏障功能。动物实验表明：腹腔注射0.2‑1.8mg/kg VHH3可有效降低疾病活动指数(DAI)，且疗效呈剂量依赖性。与现有技术相比，本发明抗体亲和力达1.23nM，具有分子量小、穿透性强、免疫原性低等优势。

Drugs covered by this patent

Patent Metadata

Patent number
CN120699157B
Jurisdiction
CN
Classification
—
Expires
2025-12-16
Drug substance claim
No
Drug product claim
No
Assignee
Ankang city central hospital
Source
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Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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