CN119950442B — 一种巯嘌呤微片及其制备方法和应用
Assigned to China Resources Double Crane Pharmaceutical Co Ltd · Expires 2025-08-05 · 1y expired
What this patent protects
本发明公开了一种巯嘌呤微片及其制备方法和应用。该巯嘌呤微片的直径为2~3mm；直径厚度比为0.85~1.15；包括如下按重量份计算的组分：巯嘌呤原料药15份~30份；填充剂40份~80份；粘合剂3份~8份；润滑剂1份~3份；崩解剂1份~3份；所述巯嘌呤原料药的D90粒径为40μm~125μm；巯嘌呤原料药的D50粒径为5μm~35μm。本发明的巯嘌呤微片的体内药代动力学性能优异，溶出效果好，具有优异的脆碎度、硬度和含量均匀度；与作为对照制剂的片剂Purinethol在吸收速度和吸收程度上均生物等效，在肿瘤治疗，尤其是儿童急性淋巴细胞白血病方面具有良好的应…
USPTO Abstract
本发明公开了一种巯嘌呤微片及其制备方法和应用。该巯嘌呤微片的直径为2~3mm；直径厚度比为0.85~1.15；包括如下按重量份计算的组分：巯嘌呤原料药15份~30份；填充剂40份~80份；粘合剂3份~8份；润滑剂1份~3份；崩解剂1份~3份；所述巯嘌呤原料药的D90粒径为40μm~125μm；巯嘌呤原料药的D50粒径为5μm~35μm。本发明的巯嘌呤微片的体内药代动力学性能优异，溶出效果好，具有优异的脆碎度、硬度和含量均匀度；与作为对照制剂的片剂Purinethol在吸收速度和吸收程度上均生物等效，在肿瘤治疗，尤其是儿童急性淋巴细胞白血病方面具有良好的应用前景。
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
Track this patent
Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.