CN Patent
CN119751424B — 一种合成甲磺酸贝舒地尔的方法
Assigned to Chongqing Changjie Pharmaceutical Co ltd · Expires 2025-12-05 · 0y expired
What this patent protects
本发明属于药物化学领域，具体涉及到一种甲磺酸贝舒地尔的合成方法。首先以2‑氯喹唑啉‑4‑胺a为原料，依次与5‑溴吲唑b发生亲核取代反应，与3‑羟基苯基硼酸d发生Suzuki偶联反应，与2‑羟基‑N‑异丙基乙酰胺f发生Mitsunobu反应，最后与甲磺酸发生成盐反应，制得甲磺酸贝舒地尔。本发明主路线短，且与现有路线相比，产率更高，利于工业化生产。
USPTO Abstract
本发明属于药物化学领域，具体涉及到一种甲磺酸贝舒地尔的合成方法。首先以2‑氯喹唑啉‑4‑胺a为原料，依次与5‑溴吲唑b发生亲核取代反应，与3‑羟基苯基硼酸d发生Suzuki偶联反应，与2‑羟基‑N‑异丙基乙酰胺f发生Mitsunobu反应，最后与甲磺酸发生成盐反应，制得甲磺酸贝舒地尔。本发明主路线短，且与现有路线相比，产率更高，利于工业化生产。
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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