CN Patent

CN118304441B — 一种肿瘤靶向的荧光探针及其制备方法和应用

Assigned to Jiangsu Province Hospital · Expires 2025-03-18 · 1y expired

What this patent protects

本发明公开了一种肿瘤靶向的荧光探针，具有式(Ⅰ)所示的结构。所述荧光探针以马来酰亚胺修饰的烷基链为桥接链段，通过巯基偶联半胱氨酸，在ICG荧光染料上修饰靶向SLC7A5的基团，通过对肿瘤细胞过表达的SLC7A5的靶向，实现肿瘤组织的靶向荧光成像。本发明还公开了所述荧光探针的制备方法和应用。

USPTO Abstract

本发明公开了一种肿瘤靶向的荧光探针，具有式(Ⅰ)所示的结构。所述荧光探针以马来酰亚胺修饰的烷基链为桥接链段，通过巯基偶联半胱氨酸，在ICG荧光染料上修饰靶向SLC7A5的基团，通过对肿瘤细胞过表达的SLC7A5的靶向，实现肿瘤组织的靶向荧光成像。本发明还公开了所述荧光探针的制备方法和应用。

Drugs covered by this patent

pafolacianine-sodium (PAFOLACIANINE SODIUM)

Patent Metadata

Patent number: CN118304441B
Jurisdiction: CN
Classification: —
Expires: 2025-03-18
Drug substance claim: No
Drug product claim: No
Assignee: Jiangsu Province Hospital
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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