CN Patent

CN117964650B — 一种枸橼酸伊沙佐米的制备方法

Assigned to Sichuan Qingmu Pharmaceutical Co ltd · Expires 2024-06-07 · 2y expired

What this patent protects

本申请属于药物合成领域，具体涉及一种枸橼酸伊沙佐米的制备方法，所述方法包括：将无水柠檬酸加热溶解于酯类溶剂或酯类溶剂和强极性溶剂的混合溶剂中，然后加入伊沙佐米游离硼酸的酯类溶剂或酯类溶剂和强极性溶剂的混合溶液，且加完伊沙佐米游离硼酸后反应体系是酯类溶剂和强极性溶剂的混合溶剂。降温至室温搅拌过夜，干燥得到枸橼酸伊沙佐米Form 2晶型，收率可达88%以上；晶型纯度高，溶剂残留低，粒径大，符合药用标准，适合工业化生产。

USPTO Abstract

本申请属于药物合成领域，具体涉及一种枸橼酸伊沙佐米的制备方法，所述方法包括：将无水柠檬酸加热溶解于酯类溶剂或酯类溶剂和强极性溶剂的混合溶剂中，然后加入伊沙佐米游离硼酸的酯类溶剂或酯类溶剂和强极性溶剂的混合溶液，且加完伊沙佐米游离硼酸后反应体系是酯类溶剂和强极性溶剂的混合溶剂。降温至室温搅拌过夜，干燥得到枸橼酸伊沙佐米Form 2晶型，收率可达88%以上；晶型纯度高，溶剂残留低，粒径大，符合药用标准，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN117964650B
Jurisdiction
CN
Classification
—
Expires
2024-06-07
Drug substance claim
No
Drug product claim
No
Assignee
Sichuan Qingmu Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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