CN Patent

CN117534678B — 一种乌帕替尼的新结晶形式及其制备方法

Assigned to Zhejiang Hongyuan Pharmaceutical Co ltd · Expires 2026-01-06 · 0y expired

What this patent protects

本发明提供了(3S,4R)‑3‑乙基‑4‑(3H‑咪唑并[1,2‑a]吡咯并[2,3‑e]吡嗪‑8‑基)‑N‑(2,2,2‑三氟乙基)吡咯烷‑1‑甲酰胺的一种新结晶形式及其制备方法。该新的结晶形式是一种水合物，命名为晶型H，它具有更好的溶解度和晶型热稳定性。这些性质可以提高(3S,4R)‑3‑乙基‑4‑(3H‑咪唑并[1,2‑a]吡咯并[2,3‑e]吡嗪‑8‑基)‑N‑(2,2,2‑三氟乙基)吡咯烷‑1‑甲酰胺在其制剂工艺过程中高温制粒条件下的晶型稳定性，并可能在一定程度上改善其在人体内的生物利用度。

USPTO Abstract

本发明提供了(3S,4R)‑3‑乙基‑4‑(3H‑咪唑并[1,2‑a]吡咯并[2,3‑e]吡嗪‑8‑基)‑N‑(2,2,2‑三氟乙基)吡咯烷‑1‑甲酰胺的一种新结晶形式及其制备方法。该新的结晶形式是一种水合物，命名为晶型H，它具有更好的溶解度和晶型热稳定性。这些性质可以提高(3S,4R)‑3‑乙基‑4‑(3H‑咪唑并[1,2‑a]吡咯并[2,3‑e]吡嗪‑8‑基)‑N‑(2,2,2‑三氟乙基)吡咯烷‑1‑甲酰胺在其制剂工艺过程中高温制粒条件下的晶型稳定性，并可能在一定程度上改善其在人体内的生物利用度。

Drugs covered by this patent

Patent Metadata

Patent number
CN117534678B
Jurisdiction
CN
Classification
—
Expires
2026-01-06
Drug substance claim
No
Drug product claim
No
Assignee
Zhejiang Hongyuan Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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