CN Patent

CN117399070B — 含有螯合配体的双手性金属协同催化体系及其不对称合成贝达喹啉的应用

Assigned to Shanghai Jiao Tong University · Expires 2025-06-24 · 1y expired

What this patent protects

本发明公开了一种含有螯合配体的双手性金属协同催化体系及其不对称合成贝达喹啉的应用。具体为：在双手性金属协同催化体系中，以一种非手性二级胺和手性氨基醇锂形成的螯合配体提高了反应的平衡常数，促使6‑溴‑3‑苄基‑2‑甲氧基喹啉(I)与3‑二甲胺基‑1‑萘基‑1‑丙酮(II)的加成反应朝正向进行，该双金属协同催化体系显著提高了目标产物(1R,2S)‑贝达喹啉的收率。

USPTO Abstract

本发明公开了一种含有螯合配体的双手性金属协同催化体系及其不对称合成贝达喹啉的应用。具体为：在双手性金属协同催化体系中，以一种非手性二级胺和手性氨基醇锂形成的螯合配体提高了反应的平衡常数，促使6‑溴‑3‑苄基‑2‑甲氧基喹啉(I)与3‑二甲胺基‑1‑萘基‑1‑丙酮(II)的加成反应朝正向进行，该双金属协同催化体系显著提高了目标产物(1R,2S)‑贝达喹啉的收率。

Drugs covered by this patent

Patent Metadata

Patent number
CN117399070B
Jurisdiction
CN
Classification
—
Expires
2025-06-24
Drug substance claim
No
Drug product claim
No
Assignee
Shanghai Jiao Tong University
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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