CN Patent

CN117342985B — 一种仑伐替尼中间体的制备方法

Assigned to Shandong New Time Pharmaceutical Co Ltd · Expires 2025-06-20 · 1y expired

What this patent protects

本发明属于医药化工领域，具体涉及一种仑伐替尼中间体的制备方法。本发明以环丙基氨基甲酸叔丁酯为起始物料，与4‑氨基‑3‑氯苯酚在催化剂作用下制得仑伐替尼关键中间体1‑(2‑氯‑4‑羟基苯基)‑3‑环丙脲，该制备方法有效避免毒性较强的氯甲酸酯等试剂的使用，使得反应操作更安全，更适合工业化放大生产。

USPTO Abstract

本发明属于医药化工领域，具体涉及一种仑伐替尼中间体的制备方法。本发明以环丙基氨基甲酸叔丁酯为起始物料，与4‑氨基‑3‑氯苯酚在催化剂作用下制得仑伐替尼关键中间体1‑(2‑氯‑4‑羟基苯基)‑3‑环丙脲，该制备方法有效避免毒性较强的氯甲酸酯等试剂的使用，使得反应操作更安全，更适合工业化放大生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN117342985B
Jurisdiction
CN
Classification
—
Expires
2025-06-20
Drug substance claim
No
Drug product claim
No
Assignee
Shandong New Time Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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