CN Patent

CN117088966A — 一种比伐芦定杂质的合成方法

Assigned to Sinopep Allsino Biopharmaceutical Co ltd · Expires 2023-11-21 · 2y expired

What this patent protects

本发明公开一种比伐芦定杂质的合成方法，属于多肽合成技术领域。本发明通过固相合成法，选择2%DBU/DMF作为脱保护试剂，从碳端到氮端依次按照顺序偶联比伐芦定杂质氨基酸，比伐芦定杂质的序列为：H‑D‑Phe‑Pro‑Arg‑Pro‑Gly‑Gly‑Gly‑Gly‑Asp‑Gly‑Asp‑Phe‑Glu‑Glu‑Ile‑Pro‑Glu‑Glu‑Tyr‑Leu‑OH；其中12位选择Fmoc‑Asp(OAll)‑OH，合成结束后加入2%的DBU/DMF溶液，进行成环操作，经裂解沉淀，得到比伐芦定杂质。本发明方法，提高了粗肽纯度，极大降低了物料成本和纯化成本。

USPTO Abstract

本发明公开一种比伐芦定杂质的合成方法，属于多肽合成技术领域。本发明通过固相合成法，选择2%DBU/DMF作为脱保护试剂，从碳端到氮端依次按照顺序偶联比伐芦定杂质氨基酸，比伐芦定杂质的序列为：H‑D‑Phe‑Pro‑Arg‑Pro‑Gly‑Gly‑Gly‑Gly‑Asp‑Gly‑Asp‑Phe‑Glu‑Glu‑Ile‑Pro‑Glu‑Glu‑Tyr‑Leu‑OH；其中12位选择Fmoc‑Asp(OAll)‑OH，合成结束后加入2%的DBU/DMF溶液，进行成环操作，经裂解沉淀，得到比伐芦定杂质。本发明方法，提高了粗肽纯度，极大降低了物料成本和纯化成本。

Drugs covered by this patent

Patent Metadata

Patent number
CN117088966A
Jurisdiction
CN
Classification
—
Expires
2023-11-21
Drug substance claim
No
Drug product claim
No
Assignee
Sinopep Allsino Biopharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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