CN Patent

CN116965376B — 一种子痫前期小鼠模型的构建方法与应用

Assigned to Nanfang Hospital of Southern Medical University · Expires 2024-01-02 · 2y expired

What this patent protects

本发明公开了一种子痫前期小鼠模型的构建方法与应用，涉及动物模型构建技术领域。本发明提供一种子痫前期小鼠模型的构建方法，包括以下步骤：(1)将雌鼠与雄鼠合笼，第二天观察到阴道栓确定该雌鼠怀孕并定为怀孕0.5天；(2)于孕中期开始对步骤(1)孕鼠进行C2神经酰胺给药至妊娠结束；(3)通过监测孕鼠血压确定是否成功构建子痫前期小鼠模型。本发明的子痫前期小鼠模型可用于子痫前期病因、发生发展机制和开发相关治疗药物的研究；本发明的子痫前期小鼠模型的构建方法操作简单，构建成功率高，构建周期短。

USPTO Abstract

本发明公开了一种子痫前期小鼠模型的构建方法与应用，涉及动物模型构建技术领域。本发明提供一种子痫前期小鼠模型的构建方法，包括以下步骤：(1)将雌鼠与雄鼠合笼，第二天观察到阴道栓确定该雌鼠怀孕并定为怀孕0.5天；(2)于孕中期开始对步骤(1)孕鼠进行C2神经酰胺给药至妊娠结束；(3)通过监测孕鼠血压确定是否成功构建子痫前期小鼠模型。本发明的子痫前期小鼠模型可用于子痫前期病因、发生发展机制和开发相关治疗药物的研究；本发明的子痫前期小鼠模型的构建方法操作简单，构建成功率高，构建周期短。

Drugs covered by this patent

Patent Metadata

Patent number
CN116965376B
Jurisdiction
CN
Classification
—
Expires
2024-01-02
Drug substance claim
No
Drug product claim
No
Assignee
Nanfang Hospital of Southern Medical University
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.