CN116854642A — 一种（s）-2-哌嗪乙腈及其盐酸盐的制备方法
Assigned to PORTON FINE CHEMICALS Ltd · Expires 2023-10-10 · 3y expired
What this patent protects
本发明公开了一种(S)‑2‑哌嗪乙腈及其盐酸盐的制备方法，包括以下步骤：使用拆分试剂将2‑(1,4‑二苄基哌嗪)乙腈拆分为(S)‑2‑(1,4‑二苄基哌嗪)乙腈；(S)‑2‑(1,4‑二苄基哌嗪)乙腈脱保护得到(S)‑2‑哌嗪乙腈。进一步，所述拆分试剂包括(‑)‑二苯甲酰‑L‑酒石酸，(+)‑二苯甲酰‑D‑酒石酸,(‑)‑二对茴香酰‑L‑酒石酸，(+)‑二对茴香酰‑D‑酒石酸,2,3‑二‑O‑对甲苯基‑L‑酒石酸，D‑(+)二对甲基苯甲酰酒石酸，L‑(‑)二对甲基苯甲酰酒石酸，L‑(+)‑酒石酸，(R)‑(‑)‑扁桃酸，D…
USPTO Abstract
本发明公开了一种(S)‑2‑哌嗪乙腈及其盐酸盐的制备方法，包括以下步骤：使用拆分试剂将2‑(1,4‑二苄基哌嗪)乙腈拆分为(S)‑2‑(1,4‑二苄基哌嗪)乙腈；(S)‑2‑(1,4‑二苄基哌嗪)乙腈脱保护得到(S)‑2‑哌嗪乙腈。进一步，所述拆分试剂包括(‑)‑二苯甲酰‑L‑酒石酸，(+)‑二苯甲酰‑D‑酒石酸,(‑)‑二对茴香酰‑L‑酒石酸，(+)‑二对茴香酰‑D‑酒石酸,2,3‑二‑O‑对甲苯基‑L‑酒石酸，D‑(+)二对甲基苯甲酰酒石酸，L‑(‑)二对甲基苯甲酰酒石酸，L‑(+)‑酒石酸，(R)‑(‑)‑扁桃酸，D‑(+)‑樟脑酸，L‑(‑)‑樟脑磺酸，D‑葡萄糖醛酸，苹果酸，奎宁酸，谷氨酸，N‑乙酰‑L‑苯丙氨酸，(‑)‑核黄素。解决了现有技术不易工业化生产的缺陷。
Drugs covered by this patent
- Krazati (ADAGRASIB) · Bristol-Myers Squibb
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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