CN Patent

CN116768885B — N2-取代双环-2-氨基嘧啶类衍生物、其制备方法及医药用途

Assigned to Zhejiang University ZJU · Expires 2026-03-24 · 0y expired

What this patent protects

发明公开了一种式(I)所示的化合物、其制备方法及医药用途，包括其光学异构体及药学上可接受的盐。本发明化合物具有FLT3和CHK1抑制活性，对多种白血病细胞株有增值抑制活性，且对AML多种突变如近膜结构域的内部串联重复突变和激酶结构域中活化环的D835点突变有效，可以克服临床上点突变带来的耐药，可在制备抗肿瘤药物中的应用。

USPTO Abstract

发明公开了一种式(I)所示的化合物、其制备方法及医药用途，包括其光学异构体及药学上可接受的盐。本发明化合物具有FLT3和CHK1抑制活性，对多种白血病细胞株有增值抑制活性，且对AML多种突变如近膜结构域的内部串联重复突变和激酶结构域中活化环的D835点突变有效，可以克服临床上点突变带来的耐药，可在制备抗肿瘤药物中的应用。

Drugs covered by this patent

Patent Metadata

Patent number
CN116768885B
Jurisdiction
CN
Classification
—
Expires
2026-03-24
Drug substance claim
No
Drug product claim
No
Assignee
Zhejiang University ZJU
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.