CN Patent

CN116715664B — 一种非奈利酮关键中间体的制备方法

Assigned to Changzhou Pharmaceutical Factory Co ltd · Expires 2025-01-17 · 1y expired

What this patent protects

本发明提供一种高手性纯度非奈利酮关键中间体的制备方法，利用D‑樟脑磺酸和有机溶剂作为化学拆分体系，制备2‑氰乙基(4S)‑4‑(4‑氰基‑2‑甲氧基苯基)‑5‑羟基‑2,8‑二甲基‑1,4‑二氢‑1,6‑萘啶‑3‑羧酸酯，ee值高达98.0％。本发明提供的制备方法反应条件温和，工艺简单，反应收率高，生产成本低，适合于工业化生产。

USPTO Abstract

本发明提供一种高手性纯度非奈利酮关键中间体的制备方法，利用D‑樟脑磺酸和有机溶剂作为化学拆分体系，制备2‑氰乙基(4S)‑4‑(4‑氰基‑2‑甲氧基苯基)‑5‑羟基‑2,8‑二甲基‑1,4‑二氢‑1,6‑萘啶‑3‑羧酸酯，ee值高达98.0％。本发明提供的制备方法反应条件温和，工艺简单，反应收率高，生产成本低，适合于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN116715664B
Jurisdiction
CN
Classification
—
Expires
2025-01-17
Drug substance claim
No
Drug product claim
No
Assignee
Changzhou Pharmaceutical Factory Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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