CN116650437A — 一种甲磺酸仑伐替尼胶囊及其制备方法
Assigned to Amicogen China Biopharm Co Ltd · Expires 2023-08-29 · 3y expired
What this patent protects
本发明提供了一种甲磺酸仑伐替尼胶囊及其制备方法，属于药物制剂技术领域。本发明将甲磺酸仑伐替尼、内加稀释剂、崩解剂、粘合剂和溶剂混合后进行湿法造粒，得到湿颗粒；将所述湿颗粒干燥，得到干颗粒；将所述干颗粒、外加稀释剂和润滑剂混合，得到甲磺酸仑伐替尼胶囊中间体颗粒；所述甲磺酸仑伐替尼胶囊中外加稀释剂的质量百分比为2～8％；将中间体颗粒进行胶囊充填，得到所述甲磺酸仑伐替尼胶囊。本发明采用外加稀释剂的方式，同时合理调控外加稀释剂占所述甲磺酸仑伐替尼胶囊的质量百分比，既保证了甲磺酸仑伐替尼胶囊制备过程的含量均一性及颗粒流动性，又保证了较好的溶出度，进而提高了生物利用…
USPTO Abstract
本发明提供了一种甲磺酸仑伐替尼胶囊及其制备方法，属于药物制剂技术领域。本发明将甲磺酸仑伐替尼、内加稀释剂、崩解剂、粘合剂和溶剂混合后进行湿法造粒，得到湿颗粒；将所述湿颗粒干燥，得到干颗粒；将所述干颗粒、外加稀释剂和润滑剂混合，得到甲磺酸仑伐替尼胶囊中间体颗粒；所述甲磺酸仑伐替尼胶囊中外加稀释剂的质量百分比为2～8％；将中间体颗粒进行胶囊充填，得到所述甲磺酸仑伐替尼胶囊。本发明采用外加稀释剂的方式，同时合理调控外加稀释剂占所述甲磺酸仑伐替尼胶囊的质量百分比，既保证了甲磺酸仑伐替尼胶囊制备过程的含量均一性及颗粒流动性，又保证了较好的溶出度，进而提高了生物利用度。
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Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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