CN Patent

CN115057854A — 马来酸阿伐曲泊帕中间体的制备方法

Assigned to HEBEI CHANGSHAN BIOCHEMICAL PHARMACEUTICAL CO Ltd · Expires 2022-09-16 · 4y expired

What this patent protects

本发明涉及一种马来酸阿伐曲泊帕中间体的制备方法，将中间体2、5,6‑二氯烟酸和吡啶在有机溶剂中，于‑10℃～20℃，滴加三氯氧磷反应得到中间体3；所述中间体2为4‑(4‑氯噻吩‑2‑基)‑5‑(4‑环己基哌嗪‑1‑基)‑1,3‑噻唑‑2‑胺，所述中间体3为5,6‑二氯‑N‑[4‑(4‑氯噻吩‑2‑基)‑5(4‑环己基哌嗪‑1‑基)‑1,3‑噻唑‑2‑基]吡啶‑3‑甲酰胺。本发明方法的污染小、制得中间体3的收率高且质量好。

USPTO Abstract

本发明涉及一种马来酸阿伐曲泊帕中间体的制备方法，将中间体2、5,6‑二氯烟酸和吡啶在有机溶剂中，于‑10℃～20℃，滴加三氯氧磷反应得到中间体3；所述中间体2为4‑(4‑氯噻吩‑2‑基)‑5‑(4‑环己基哌嗪‑1‑基)‑1,3‑噻唑‑2‑胺，所述中间体3为5,6‑二氯‑N‑[4‑(4‑氯噻吩‑2‑基)‑5(4‑环己基哌嗪‑1‑基)‑1,3‑噻唑‑2‑基]吡啶‑3‑甲酰胺。本发明方法的污染小、制得中间体3的收率高且质量好。

Drugs covered by this patent

Patent Metadata

Patent number
CN115057854A
Jurisdiction
CN
Classification
—
Expires
2022-09-16
Drug substance claim
No
Drug product claim
No
Assignee
HEBEI CHANGSHAN BIOCHEMICAL PHARMACEUTICAL CO Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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