CN Patent

CN114246872B — 一种改善羟乙磺酸哌柏西利流动性的工艺方法及组合物

Assigned to Nanjing Gritpharma Co ltd · Expires 2024-02-06 · 2y expired

What this patent protects

本发明公开了一种改善羟乙磺酸哌柏西利流动性的工艺方法及组合物，属于药物制剂领域。方法包括将羟乙磺酸哌柏西利与药学上可接受的辅料进行制粒的步骤，得到的颗粒振实密度为0.55～0.72g/mL，休止角小于等于44°。本发明的工艺方法使羟乙磺酸哌柏西利组合物在进行胶囊灌装时，颗粒流动性较好，制备的羟乙磺酸哌柏西利胶囊含量均一，稳定性好，质量可控。制备方法操作便捷，易于掌握和调节，生产放大可控性好。

USPTO Abstract

本发明公开了一种改善羟乙磺酸哌柏西利流动性的工艺方法及组合物，属于药物制剂领域。方法包括将羟乙磺酸哌柏西利与药学上可接受的辅料进行制粒的步骤，得到的颗粒振实密度为0.55～0.72g/mL，休止角小于等于44°。本发明的工艺方法使羟乙磺酸哌柏西利组合物在进行胶囊灌装时，颗粒流动性较好，制备的羟乙磺酸哌柏西利胶囊含量均一，稳定性好，质量可控。制备方法操作便捷，易于掌握和调节，生产放大可控性好。

Drugs covered by this patent

Patent Metadata

Patent number
CN114246872B
Jurisdiction
CN
Classification
—
Expires
2024-02-06
Drug substance claim
No
Drug product claim
No
Assignee
Nanjing Gritpharma Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.