CN Patent

CN113842379B — 倍他洛尔作为ndm-1抑制剂或抗生素保护剂的新用途

Assigned to Northeast Agricultural University · Expires 2024-04-23 · 2y expired

What this patent protects

本发明公开了倍他洛尔作为NDM‑1抑制剂或抗生素保护剂的新用途，属于倍他洛尔新医药用途领域。本发明通过NDM‑1酶抑制试验、微量棋盘稀释法以及时间‑杀菌曲线等试验发现倍他洛尔能够显著抑制NDM‑1的活性并恢复美罗培南对产NDM‑1大肠杆菌的抗菌活性。本发明由此确定倍他洛尔可作为NDM‑1抑制剂，其与β‑内酰胺类抗生素联合应用能够减少甚至消除NDM‑1对β‑内酰胺类抗生素的水解、恢复耐药菌对β‑内酰胺类抗生素的敏感性。

USPTO Abstract

本发明公开了倍他洛尔作为NDM‑1抑制剂或抗生素保护剂的新用途，属于倍他洛尔新医药用途领域。本发明通过NDM‑1酶抑制试验、微量棋盘稀释法以及时间‑杀菌曲线等试验发现倍他洛尔能够显著抑制NDM‑1的活性并恢复美罗培南对产NDM‑1大肠杆菌的抗菌活性。本发明由此确定倍他洛尔可作为NDM‑1抑制剂，其与β‑内酰胺类抗生素联合应用能够减少甚至消除NDM‑1对β‑内酰胺类抗生素的水解、恢复耐药菌对β‑内酰胺类抗生素的敏感性。

Drugs covered by this patent

Patent Metadata

Patent number
CN113842379B
Jurisdiction
CN
Classification
—
Expires
2024-04-23
Drug substance claim
No
Drug product claim
No
Assignee
Northeast Agricultural University
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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