CN Patent

CN113181117B — 一种紫草素和蒽环类化疗药共载脂质体及其制备方法和应用

Assigned to Shenyang Pharmaceutical University · Expires 2022-08-26 · 4y expired

What this patent protects

本发明公开了一种包含紫草素和蒽环类化疗药物脂质体的制备方法及其在协同抗肿瘤免疫疗法中的应用，属于药物制剂技术领域。首先，将紫草素和蒽环类药物米托蒽醌或阿霉素同时包封于脂质体内，用共载脂质体以细胞毒实验、摄取实验和ICD诱导能力来筛选协同比例，所制备的双载药脂质体具有pH/GSH双响应释放特性，能够将药物递送到肿瘤组织，协同诱导抗肿瘤效果并降低两药的给药剂量，减少药物毒副作用，实现了增效减毒的目的。

USPTO Abstract

本发明公开了一种包含紫草素和蒽环类化疗药物脂质体的制备方法及其在协同抗肿瘤免疫疗法中的应用，属于药物制剂技术领域。首先，将紫草素和蒽环类药物米托蒽醌或阿霉素同时包封于脂质体内，用共载脂质体以细胞毒实验、摄取实验和ICD诱导能力来筛选协同比例，所制备的双载药脂质体具有pH/GSH双响应释放特性，能够将药物递送到肿瘤组织，协同诱导抗肿瘤效果并降低两药的给药剂量，减少药物毒副作用，实现了增效减毒的目的。

Drugs covered by this patent

Patent Metadata

Patent number
CN113181117B
Jurisdiction
CN
Classification
—
Expires
2022-08-26
Drug substance claim
No
Drug product claim
No
Assignee
Shenyang Pharmaceutical University
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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