CN Patent

CN113087666B — 无定形喹啉甲酰胺衍生物的制备方法

Assigned to Nanjing Chia Tai Tianqing Pharmaceutical Co Ltd · Expires 2021-12-14 · 4y expired

What this patent protects

本发明涉及无定形喹啉甲酰胺衍生物的制备方法，包括将仑伐替尼甲磺酸盐晶型C溶于叔丁醇/水混合溶剂、搅拌、过滤、收集滤液，冻干得到无定形。该方法得到的无定形纯度高，冻干均匀，样品外观蓬松，含水量低，溶残合格，冻干溶剂对仪器设备损伤小、操作安全适于工业生产，得到的无定形在制剂过程中不会发生凝胶现象，以无定形为原料制成的胶囊具有溶出快的优点。

USPTO Abstract

本发明涉及无定形喹啉甲酰胺衍生物的制备方法，包括将仑伐替尼甲磺酸盐晶型C溶于叔丁醇/水混合溶剂、搅拌、过滤、收集滤液，冻干得到无定形。该方法得到的无定形纯度高，冻干均匀，样品外观蓬松，含水量低，溶残合格，冻干溶剂对仪器设备损伤小、操作安全适于工业生产，得到的无定形在制剂过程中不会发生凝胶现象，以无定形为原料制成的胶囊具有溶出快的优点。

Drugs covered by this patent

lenvatinib-mesylate (LENVATINIB MESYLATE)

Patent Metadata

Patent number: CN113087666B
Jurisdiction: CN
Classification: —
Expires: 2021-12-14
Drug substance claim: No
Drug product claim: No
Assignee: Nanjing Chia Tai Tianqing Pharmaceutical Co Ltd
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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