CN Patent

CN113004202B — 一种高纯度托伐普坦的制备方法

Assigned to Chengdu Beite Pharmaceutical Co ltd · Expires 2023-10-24 · 3y expired

What this patent protects

本发明提供了制备高纯度托伐普坦的方法。具体而言，本发明通过结晶纯化控制中间体N‑(4‑(7‑氯‑5‑氧代‑2,3,4,5‑四氢‑1H‑苯并[b]氮杂‑1‑基羰基)‑3‑甲基苯基)‑2‑甲基苯甲酰胺的质量，得到高纯度的该中间体，通过对该中间体还原得到托伐普坦的工艺条件进行控制和后续纯化得到高纯度托伐普坦。本发明成本低，制备过程简单，反应条件温和，制得的托伐普坦纯度高达99.9％以上，收率达80％以上，有利于工业化生产。

USPTO Abstract

本发明提供了制备高纯度托伐普坦的方法。具体而言，本发明通过结晶纯化控制中间体N‑(4‑(7‑氯‑5‑氧代‑2,3,4,5‑四氢‑1H‑苯并[b]氮杂‑1‑基羰基)‑3‑甲基苯基)‑2‑甲基苯甲酰胺的质量，得到高纯度的该中间体，通过对该中间体还原得到托伐普坦的工艺条件进行控制和后续纯化得到高纯度托伐普坦。本发明成本低，制备过程简单，反应条件温和，制得的托伐普坦纯度高达99.9％以上，收率达80％以上，有利于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN113004202B
Jurisdiction
CN
Classification
—
Expires
2023-10-24
Drug substance claim
No
Drug product claim
No
Assignee
Chengdu Beite Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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