CN Patent

CN112957333B — 注射用磷酸特地唑胺及其制备方法

Assigned to Hainan General & Comrie Pharmaceutical Co ltd · Expires 2022-11-22 · 3y expired

What this patent protects

本发明涉及一种注射用磷酸特地唑胺及其制备方法，其制备方法为：通过加入pH调节剂得磷酸特地唑胺盐溶液，依次加入二甲亚砜和二氯乙烷一次析晶除杂，后加入磁性膨润土脱色，再加入乙腈和乙醚二次洗净除杂，得磷酸特地唑胺原料药，收率90.5%、HPLC检测纯度99.91%，其析晶速度快，适合规模化生产，且除杂效果好。其注射剂为由磷酸特地唑胺原料药、甘露醇、注射用水和pH调节剂构成的冻干剂。

USPTO Abstract

本发明涉及一种注射用磷酸特地唑胺及其制备方法，其制备方法为：通过加入pH调节剂得磷酸特地唑胺盐溶液，依次加入二甲亚砜和二氯乙烷一次析晶除杂，后加入磁性膨润土脱色，再加入乙腈和乙醚二次洗净除杂，得磷酸特地唑胺原料药，收率90.5%、HPLC检测纯度99.91%，其析晶速度快，适合规模化生产，且除杂效果好。其注射剂为由磷酸特地唑胺原料药、甘露醇、注射用水和pH调节剂构成的冻干剂。

Drugs covered by this patent

Patent Metadata

Patent number
CN112957333B
Jurisdiction
CN
Classification
—
Expires
2022-11-22
Drug substance claim
No
Drug product claim
No
Assignee
Hainan General & Comrie Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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