CN Patent

CN112730682B — 一种抗病毒药物临床研究血浆样本中奥司他韦及代谢物奥司他韦酸浓度的生物分析方法

Assigned to Suzhou Haike Medical Technology Co ltd · Expires 2022-06-17 · 4y expired

What this patent protects

本发明涉及一种抗病毒药物临床研究血浆样本中奥司他韦及代谢物奥司他韦酸浓度的生物分析方法，通过LC‑MS/MS对血浆中奥司他韦及代谢物奥司他韦酸进行分析。本发明方法优选采用蛋白沉淀预处理方法，以奥司他韦‑d5和奥司他韦酸‑d3为内标，采用Luna PFP色谱柱，梯度洗脱，电喷雾电离源(ESI)串联质谱检测。本发明操作简便、分析速度快、灵敏度高、线性范围合适，满足临床研究大批量样品分析需求。

USPTO Abstract

本发明涉及一种抗病毒药物临床研究血浆样本中奥司他韦及代谢物奥司他韦酸浓度的生物分析方法，通过LC‑MS/MS对血浆中奥司他韦及代谢物奥司他韦酸进行分析。本发明方法优选采用蛋白沉淀预处理方法，以奥司他韦‑d5和奥司他韦酸‑d3为内标，采用Luna PFP色谱柱，梯度洗脱，电喷雾电离源(ESI)串联质谱检测。本发明操作简便、分析速度快、灵敏度高、线性范围合适，满足临床研究大批量样品分析需求。

Drugs covered by this patent

Patent Metadata

Patent number
CN112730682B
Jurisdiction
CN
Classification
—
Expires
2022-06-17
Drug substance claim
No
Drug product claim
No
Assignee
Suzhou Haike Medical Technology Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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