CN Patent

CN112574234B — 一种海鞘素衍生物的制备方法

Assigned to Jiangsu Hengrui Medicine Co Ltd · Expires 2022-05-24 · 4y expired

What this patent protects

本公开涉及一种海鞘素衍生物的制备方法。具体而言，提供了一种制备ET‑743、PM‑1183或其可药用盐的方法，该方法包括式(a)所示化合物在金属钯‑配体催化下甲基化以形成式(b)所示化合物的步骤，所用甲基化试剂如甲基硼酸、甲基硼酸频哪醇酯或甲基三氟硼酸钾。该工艺操作简便、收率且所样品质量，适于大规模生产。

USPTO Abstract

本公开涉及一种海鞘素衍生物的制备方法。具体而言，提供了一种制备ET‑743、PM‑1183或其可药用盐的方法，该方法包括式(a)所示化合物在金属钯‑配体催化下甲基化以形成式(b)所示化合物的步骤，所用甲基化试剂如甲基硼酸、甲基硼酸频哪醇酯或甲基三氟硼酸钾。该工艺操作简便、收率且所样品质量，适于大规模生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN112574234B
Jurisdiction
CN
Classification
—
Expires
2022-05-24
Drug substance claim
No
Drug product claim
No
Assignee
Jiangsu Hengrui Medicine Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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