CN Patent

CN112500343B — 5,7-二氯-1,2,3,4-四氢异喹啉盐酸盐的合成方法

Assigned to Shandong Jincheng Courage Chemical Co ltd · Expires 2023-04-07 · 3y expired

What this patent protects

本发明涉及一种5,7‑二氯‑1,2,3,4‑四氢异喹啉盐酸盐的合成方法，属于医药中间体合成技术领域。本发明所述的方法包括以3,5‑二氯苯甲醛为原料，通过制备席夫碱、还原、关环及还原酸化反应得到5,7‑二氯‑1,2,3,4‑四氢异喹啉盐酸盐，总收率在60％以上。本发明避免了使用昂贵的原料，且工艺路线简单，条件温和，生产成本低，适合工业化生产。

USPTO Abstract

本发明涉及一种5,7‑二氯‑1,2,3,4‑四氢异喹啉盐酸盐的合成方法，属于医药中间体合成技术领域。本发明所述的方法包括以3,5‑二氯苯甲醛为原料，通过制备席夫碱、还原、关环及还原酸化反应得到5,7‑二氯‑1,2,3,4‑四氢异喹啉盐酸盐，总收率在60％以上。本发明避免了使用昂贵的原料，且工艺路线简单，条件温和，生产成本低，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN112500343B
Jurisdiction
CN
Classification
—
Expires
2023-04-07
Drug substance claim
No
Drug product claim
No
Assignee
Shandong Jincheng Courage Chemical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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