CN Patent

CN112430235B — 一种pf-06651600中间体的制备方法

Assigned to Dongguan Dongyangguang Generic Research And Development Co ltd · Expires 2024-04-05 · 2y expired

What this patent protects

本发明涉及一种PF‑06651600中间体的制备方法，属于药物化学领域。所述方法以(5R)‑2‑甲基‑5‑氨基‑1‑苄基哌啶或其盐为原料，经过取代反应、拆分、脱Ts保护、脱苄基得到目标化合物(2S,5R)‑5‑((7H‑吡咯)氨基)‑2‑甲基哌啶(化合物09)，化合物09经过酰胺化可以得到PF‑06651600。该制备方法原料而得，价格低廉，降低生产成本，反应条件温和，产品纯度高，收率高，操作安全，可用于工业化生产。

USPTO Abstract

本发明涉及一种PF‑06651600中间体的制备方法，属于药物化学领域。所述方法以(5R)‑2‑甲基‑5‑氨基‑1‑苄基哌啶或其盐为原料，经过取代反应、拆分、脱Ts保护、脱苄基得到目标化合物(2S,5R)‑5‑((7H‑吡咯)氨基)‑2‑甲基哌啶(化合物09)，化合物09经过酰胺化可以得到PF‑06651600。该制备方法原料而得，价格低廉，降低生产成本，反应条件温和，产品纯度高，收率高，操作安全，可用于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN112430235B
Jurisdiction
CN
Classification
—
Expires
2024-04-05
Drug substance claim
No
Drug product claim
No
Assignee
Dongguan Dongyangguang Generic Research And Development Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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