CN Patent

CN112047924B — 一种沃克洛多的制备方法

Assigned to Shandong Huihai Pharmaceutical& Chemical Co ltd · Expires 2023-04-18 · 3y expired

What this patent protects

本发明涉及一种沃克洛多的制备方法，以6‑溴水杨醛为原料，与3‑(氯甲基)‑2‑(1‑异丙基‑1H‑吡唑‑5‑基)吡啶盐酸盐反应得到2‑溴‑6‑((2‑(1‑异丙基‑1H‑吡唑‑5‑基)吡啶‑3‑基)甲氧基)苯甲醛，再在RockPhos Pd G3的催化下进行温和的溴代芳香烃的酚羟基化反应，得到沃克洛多。工艺步骤短，反应条件温和，操作简便，避免了易燃易爆试剂的使用和反应条件限制。

USPTO Abstract

本发明涉及一种沃克洛多的制备方法，以6‑溴水杨醛为原料，与3‑(氯甲基)‑2‑(1‑异丙基‑1H‑吡唑‑5‑基)吡啶盐酸盐反应得到2‑溴‑6‑((2‑(1‑异丙基‑1H‑吡唑‑5‑基)吡啶‑3‑基)甲氧基)苯甲醛，再在RockPhos Pd G3的催化下进行温和的溴代芳香烃的酚羟基化反应，得到沃克洛多。工艺步骤短，反应条件温和，操作简便，避免了易燃易爆试剂的使用和反应条件限制。

Drugs covered by this patent

Patent Metadata

Patent number
CN112047924B
Jurisdiction
CN
Classification
—
Expires
2023-04-18
Drug substance claim
No
Drug product claim
No
Assignee
Shandong Huihai Pharmaceutical& Chemical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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