CN112006995A — 一种氢溴酸伏硫西汀片的制备方法
Assigned to CSPC Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd · Expires 2020-12-01 · 5y expired
What this patent protects
本发明提供一种氢溴酸伏硫西汀片的制备方法。所述氢溴酸伏硫西汀片由底片和包衣组成。本发明在制粒过程中通过控制流化床进风温度75℃‑85℃、进风量500m 3 /h‑700m 3 /h，使得制得的颗粒松密度在0.3‑0.4g/ml、水分1.5％～3％范围内，压片制得的底片相比于对比例次品率低、片重差异小，同时解决了对比例底片早期溶出缓慢的问题，有很好的产业应用前景。
USPTO Abstract
本发明提供一种氢溴酸伏硫西汀片的制备方法。所述氢溴酸伏硫西汀片由底片和包衣组成。本发明在制粒过程中通过控制流化床进风温度75℃‑85℃、进风量500m 3 /h‑700m 3 /h，使得制得的颗粒松密度在0.3‑0.4g/ml、水分1.5％～3％范围内，压片制得的底片相比于对比例次品率低、片重差异小，同时解决了对比例底片早期溶出缓慢的问题，有很好的产业应用前景。
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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